Treatment of progressive supranuclear palsy
On 16 July 2016 NeuroTau Inc. obtained US FDA orphan drug designation for tolfenamic acid in the treatment of Progressive Supranuclear Palsy (PSP)
Public summary of opinion on orphan designation – Tolfenamic acid for the treatment of progressive supranuclear palsy
On 17 February 2016, NeuroTau partner was granted orphan designation (EU/3/16/1613) by the European Commission for tolfenamic acid for the treatment of progressive supranuclear palsy.
Treatment of Frontotemporal Dementia
On 16 July 2016 NeuroTau Inc. obtained US FDA orphan drug designation for tolfenamic acid in the treatment of Frontotemporal Dementia (FTD)
Public summary of opinion on orphan designation – Tolfenamic acid for the treatment of behavioural variant frontotemporal dementia
On 17 February 2016, NeuroTau Inc partner was granted orphan designation (EU/3/16/1614) by the European Commission for tolfenamic acid for the treatment of behavioural variant frontotemporal dementia.
Evaluation of Tolfenamic Acid in Individuals With PSP at 12-Weeks
NeuroTau Inc announces listing of its clinical trial “Evaluation of Tolfenamic Acid in Individuals with Progressive Supranuclear Palsy (PSP)” on ClinicalTrials.gov and intention to begin study in Q1/2021
Tolfenamic acid and pancreatic cancer growth, angiogenesis, and Sp protein degradation
This cancer paper tested various classes of NSAIDS and showed that fenamates have a unique independent mechanism of action that alters the levels of the SP family of transcription factors.
Mefenamic acid shows neuroprotective effects and improves cognitive impairment in vitro and in vivo Alzheimer’s disease models
This manuscript demonstrated the first published role for a protective effect of fenamates in AD models.
The ability of tolfenamic acid to penetrate the brain: a model for testing the brain disposition of candidate Alzheimer’s drugs using multiple platforms
The findings of these studies provide evidence that fenamates can penetrate the brain in sufficient quantities to have an impact on targets therein.
Short-term treatment with tolfenamic acid improves cognitive functions in Alzheimer’s disease mice
This study provides evidence for the ability of fenamates to improve cognitive function and alter amyloid biomarker levels over a short period of treatment via a mechanism that involves Sp1.
Reduction of amyloid-β deposition and attenuation of memory deficits by tolfenamic acid
The data presented in this published work shows that fenamates can improve memory and reduce amyloid plaque burden levels in transgenic mouse models of AD.
Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer’s disease in rodent models
This paper show that several clinically approved and widely used NSAIDs of the fenamate class are effective and selective inhibitors of the NLRP3 inflammasome via inhibition of the volume-regulated anion channel in macrophages, independently of COX enzymes.
Tolfenamic Acid: A Modifier of the Tau Protein and its Role in Cognition and Tauopathy
In this study, treatment with tolfenamic acid improved spatial learning deficits and memory impairments in young and aged hTau mice along with reductions in total tau as well as in site specific hyperphosphorylation of tau. Furthermore immunohistochemical analysis for phosphorylated tau protein revealed reduced staining in the frontal cortex, hippocampus, and striatum in animals treated […]
Tolfenamic acid inhibits GSK-3β and PP2A mediated tau hyperphosphorylation in Alzheimer’s disease models
Altogether, results from this work show that tolfenamic acid not only decreased SP1/CDK5-mediated tau phosphorylation, but also inhibited GSK-3β and PP2A-mediated tau hyperphosphorylation in AD models.